Welcome

METVES II

Extracellular vesicles (EVs) are cell-derived particles present in body fluids, and EVs have excellent potential as next-generation biomarkers for early diagnosis of common diseases, such as cancer and thrombosis. This project aims to tap the clinical potential of EVs by developing traceable measurements of number concentration, size distribution, refractive index and fluorescence intensity of cell-specific EVs in human blood and urine. The project will develop synthetic reference materials with physical properties resembling EVs, ready-to-use biological test samples, and instrumentation and procedures to standardise EV measurements in clinical laboratories, which will be evaluated in an inter-laboratory comparison study.

This website contains news, a project summary, and a description of the work packages of Joint Research Project METVES II. In addition, you can find a list with the involved people and institutes, an overview of the generated output, and links relevant to the project. If you have any questions, please do not hesitate to contact us.

Agenda

• November 24^th 2022: Workshop on standardization of extracellular vesicle concentration measurements: from single to multicenter studies.

News

• 27 January 2021: The new publishable Summary for 18HLT01 METVES II has been released.
• 14 January 2021: We are working on the midterm progress report of METVES II, which offers a great opportunity to summarize our output and update this website. Hitherto, we published 3 peer-reviewed manuscript, we presented 10 posters, we presented 15 presentations, we wrote 3 public reports, and we recorded 5 videos.
• University of Helsinki helps to find solu­tions to the diagnostics and treat­ment of severe dis­eases through research on ex­tra­cel­lu­lar ves­icles

Latest articles

• Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size, and concentration (pdf, 8 MB)
• Reliable measurements of extracellular vesicles by clinical flow cytometry (pdf, 1 MB)
• Particle size distribution of bimodal silica nanoparticles: a comparison of different measurement techniques (pdf, 2 MB)

Latest presentations

• Protection by extracellular vesicles & standardization of laboratory measurements
• Perspective of BAM on Advanced Materials
• Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo-implications for biomarker discovery

Last video: METVES II interlaboratory comparison study webinar

Funding

This project (18HLT01) has received funding from the EMPIR program co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation program.