Standardisation of concentration measurements of extracellular vesicles for medical diagnoses


This page contains news items related to METVES II and the news archive of the preceding METVES project.



14 January 2021 
We are working on the midterm progress report of METVES II, which offers a great opportunity to summarize our output and update this website. Hitherto, we published 3 peer-reviewed manuscript, we presented 10 posters, we presented 15 presentations, we wrote 3 public reports, and we recorded 5 videos.


12 February 2019 
The first progress meeting of METVES II took place in Budapest. In sum, the first preliminary reference materials (hollow organosilica beads, low refractive index particles, and liposomes) as well as ready-to-use biological test samples have been produced and will soon be characterized.

METVES II news archive


17 October 2019 
MSU approved the first deliverable of METVES II: "Report on the requirements of clinically relevant synthetic reference materials to standardise concentration measurements of EVs based on stakeholder needs."
17 June 2019 
METVES II officially started with the kick-off meeting in Delft.

METVES news archive


11 November 2015 
Our manuscript on handling and storage of human body fluids for analysis of extracellular vesicles (pdf, 4 MB) is published in the Journal of Extracellular Vesicles.
21 October 2015 
The final summary of the METVES project (pdf, <1 MB) is made available to download.
28 May 2015 
METVES organizes a workshop on the Metrological Characterization of Microvesicles.
27 February 2015 
Four videos with standard operation procedures of vesicle isolation and detection are placed on YouTube.


1 August 2014 
8 July 2014 
Our manuscript on co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation (pdf, <1 MB) is accepted for publication in the Journal of Extracellular Vesicles.
25 April 2014 
1 January 2014 
Our manuscript on traceable size determination of extracellular vesicles (pdf, 2 MB) is published in the Journal of Extracellular Vesicles.


21 June 
Our manuscript on innovation in detection of microparticles and exosomes (pdf, <1 MB) is published in the Journal of Thrombosis and Haemostasis.
19 June 
The first METVES report, on the needs, specifications and commercial sources of microvesicle reference materials (pdf, <1 MB), is made available to download.


20 December 
Our manuscript on extracellular vesicles in physiological and pathological conditions is accepted for publication in Blood Reviews.
9 November 
Article titled ‘Whispering tumors’ (pdf, <1 MB) by Wybo Algra published in the Dutch national newspaper Trouw (in Dutch).